WHAT IS Subutex?
Subutex is used to treat narcotic (opioid) dependence. Subutex works by preventing withdrawl symptoms, since it is actually a type of narcotic (opioid) itself. Subutex should be used as part of a complete narcotic dependence treatment plan.INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be necessary if you are taking MAO inhibitors (e.g., furazolidone, linezolid, moclobemide, phenelzine, procarbazine, selegiline, isocarboxazid, tranylcypromine), medicines which decrease liver metabolism (inhibitors of cytochrome 3A4 enzymes such as itraconazole, ketoconazole, erythromycin, clarithromycin, ritonavir, indinavir, saquinavir), local anesthetics (e.g., bupivacaine), or sedative medicines (benzodiazepines such as diazepam, lorazepam). Deaths have occurred when buprenorphine has been misused by injecting it ("shooting up"), especially when used in combination with benzodiazepines (e.g., diazepam) or other depressants such as alcohol or additional narcotics. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be necessary if you are taking other medicines which cause drowsiness such as medicine for sleep (e.g., sedatives), tranquilizers, anti-anxiety medicines (e.g., temazepam), narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), anti-seizure medicines (e.g., carbamazepine), muscle relaxants, or antihistamines that cause drowsiness (e.g., diphenhydramine). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions, including lung or liver disease, serious head injury or brain diseases (lesions), low thyroid problems (hypothyroidism), adrenal problems (Addison's disease), psychiatric problems (toxic psychosis), difficulty urinating (enlarged prostate or urethral narrowing), acute alcoholism (with or without delirium tremens), spinal problems (kyphoscoliosis), gallbladder (biliary tract) disease and other abdominal conditions, allergies, pregnancy, or breast-feeding. Contact your doctor or pharmacist if you have any questions or concerns about Subutex 2mg.Follow the directions for using Subutex 2mg provided by your doctor. TO USE SUBLINGUAL TABLETS: do not swallow, crush, or chew the tablet. Place the tablet under your tongue. Allow the tablet to slowly dissolve. Do not eat, drink or smoke while the tablet is dissolving. If you are to use more than one tablet each day, you may place all of the tablets under your tongue at once. If this is not possible, then you may place two tablets at a time under your tongue, until they all have dissolved. Subutex 2mg is generally used once daily for 2 days, or as directed by your doctor. Then your doctor usually will switch you to the buprenorphine/naloxone medicine, which works the same way as Subutex 2mg. Use Subutex 2mg regularly to get the most benefit from it. To help you remember, use it at the same time each day. DO NOT INJECT ("shoot up") buprenorphine. Injecting it is dangerous and you may have severe withdrawal symptoms (see Side Effects section). Consult your doctor or pharmacist for more details. Buprenorphine can cause withdrawal symptoms if you use it soon after using narcotics such as heroin, morphine, or methadone. Follow your doctor's instructions for your treatment plan. STORE SUBUTEX 2mg at room temperature 77 degrees F (25 degrees C) in a tightly-closed container away from heat, light, or moisture. Brief storage between 59 and 86 degrees F (15-30 degrees C) is permitted. IF YOU MISS A DOSE OF SUBUTEX 2mg, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do NOT take 2 doses at once. DO NOT EXCEED THE RECOMMENDED DOSE or take Subutex 2mg for longer than prescribed without checking with your doctor. If used for an extended period of time, DO NOT STOP USING SUBUTEX 2mg SUDDENLY without first checking with your doctor, or withdrawal symptoms may occur. IT IS IMPORTANT that you keep all doctor and laboratory appointments while you are taking Subutex 2mg. Certain laboratory and/or medical tests (e.g., liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for details. SUBUTEX 2mg MAY CAUSE DIZZINESS OR DROWSINESS. DO NOT DRIVE, OPERATE MACHINERY, OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you know how you react to Subutex 2mg. Using Subutex 2mg alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. AVOID ALCOHOLIC BEVERAGES. If dizziness occurs, sit up or stand up slowly. CAUTION IS ADVISED when using Subutex 2mg in the elderly because they may be more sensitive to the effects of the medicine, especially the possible decreased breathing and drowsiness effects. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using Subutex 2mg during pregnancy. SUBUTEX 2mg IS EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while taking Subutex 2mg. SIDE EFFECTS, that may go away during treatment, include drowsiness, dizziness, constipation, headache, nausea, or vomiting. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR IMMEDIATELY if you experience any unlikely but serious side effects including slow/shallow breathing, mental/mood changes (e.g., depression), or stomach/abdominal pain. CHECK WITH YOUR DOCTOR IMMEDIATELY if you experience any highly unlikely but very serious side effects including dark urine, yellowing of eyes or skin, or vision changes. AN ALLERGIC REACTION to Subutex 2mg is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or trouble breathing. NARCOTIC WITHDRAWAL SYMPTOMS include diarrhea, severe mental/mood changes (such as anxiety, irritability, trouble sleeping), muscle stiffness, or shakiness. If such symptoms occur, NOTIFY YOUR DOCTOR OR PHARMACIST IMMEDIATELY. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include excessive drowsiness, severe dizziness, very slow and shallow breathing. Carry an identification card at all times that says you are taking Subutex 2mg. DO NOT SHARE SUBUTEX 2mg with others for whom it was not prescribed. DO NOT USE SUBUTEX 2mg for other health conditions. Tell your doctors that you use Subutex 2mg and have regularly used narcotics, especially in cases of emergency treatment. KEEP SUBUTEX 2mg out of the reach of children and pets. 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